I think it would be useful if we could create multiple personalized results groups. For example, a "Work" group could be created that you could pin/raise/lower/remove certain domains that focuses on the area of your work. Then you could have a separate personal group that would have a different set of domains that are pinned/raised/lowered/removed, etc. It'd also be useful to be able to create groups for various other topics as well and personalizing the results for them accordingly.
As explained above I think the ability to create multiple personalized results groups would be helpful to tailor results based on what you're doing. For example while working, or researching a specific topic having personalized results tailored for those topics could help finding relevant information easier.